"What’s your arm strength like? I’m looking for someone who can open pickle jars for me when the inevitable osteoporosis sets in."
I was a bit upset that she never responded. Probably has something to do with my brittle ego.
*1. The underlying mechanism in all cases of osteoporosis is an imbalance between bone resorption and bone formation.
*2. The activation of osteoclasts is regulated by various molecular signals, of which RANKL (receptor activator of nuclear factor kappa-B ligand) is one of the best studied. This molecule is produced by osteoblasts (among other cells), and stimulates RANK (receptor activator of nuclear factor κB). Osteoprotegerin (OPG) binds RANKL before it has an opportunity to bind to RANK, and hence suppresses its ability to increase bone resorption.
*3. Source: Wikipedia > Osteoporosis > Parthenogenesis.